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Article

Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia.

Genes - 16 Nov 2022

Refisch Alexander, Komatsuzaki Shoko, Ungelenk Martin, Schumann Andy, Chung Ha-Yeun, Schilling Susann S, Jantzen Wibke, Schröder Sabine, Nöthen Markus M, Mühleisen Thomas W, Hübner Christian A, Bär Karl-Jürgen

Abstract excerpt

BACKGROUND: Cardiac autonomic dysfunction (CADF) is a major contributor to increased cardiac mortality in schizophrenia patients. The aberrant function of voltage-gated ion channels, which are widely distributed in the brain and heart, may link schizophrenia and CADF. In search of channel-encoding genes that are associated with both CADF and schizophrenia, CACNA1C and KCNH2 are promising candidates. In this...

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Identifiers

PMID: 36421807
DOI: 10.3390/genes13112132
PMCID: PMC9691174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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