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Article

Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements.

Molecular and cellular biology - 15 Feb 2017

Hirano Ikuo, Suzuki Norio, Yamazaki Shun, Sekine Hiroki, Minegishi Naoko, Shimizu Ritsuko, Yamamoto Masayuki

Abstract excerpt

The erythropoietin (Epo) gene is under tissue-specific inducible regulation. Because the kidney is the primary EPO-producing tissue in adults, impaired EPO production in chronic kidney disorders results in serious renal anemia. The Epo gene contains a liver-specific enhancer in the 3' region, but the kidney-specific enhancer for gene expression in renal EPO-producing (REP) cells remains elusive. Here, we examined...

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Identifiers

PMID: 27920250
DOI: 10.1128/MCB.00451-16
PMCID: PMC5288576

Genes

EPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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