Article
Plasticity of renal erythropoietin-producing cells governs fibrosis.
Journal of the American Society of Nephrology : JASN - 1 Oct 2013
Souma Tomokazu, Yamazaki Shun, Moriguchi Takashi, Suzuki Norio, Hirano Ikuo, Pan Xiaoqing, Minegishi Naoko, Abe Michiaki, Kiyomoto Hideyasu, Ito Sadayoshi, Yamamoto Masayuki
Abstract excerpt
CKD progresses with fibrosis and erythropoietin (Epo)-dependent anemia, leading to increased cardiovascular complications, but the mechanisms linking Epo-dependent anemia and fibrosis remain unclear. Here, we show that the cellular phenotype of renal Epo-producing cells (REPs) alternates between...
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