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Article

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.

1 Oct 1991

Abstract excerpt

Synthesis of erythropoietin, the primary humoral regulator of erythropoiesis, in liver and kidney is inducible by anemia or hypoxia. Analysis of human erythropoietin gene expression in transgenic mice revealed that sequences located 6-14 kilobases 5' to the gene direct expression to the kidney, whereas sequences within the immediate 3'-flanking region control hepatocyte-specific expression. Human erythropoietin...

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PMID: 1924331
DOI: 10.1073/pnas.88.19.8725

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