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Article

Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements.

Molecular and cellular biology - 1 Mar 1990

Semenza G L, Dureza R C, Traystman M D, Gearhart J D, Antonarakis S E

Abstract excerpt

Erythropoietin (EPO) is the primary humoral regulator of mammalian erythropoiesis. The single-copy EPO gene is normally expressed in liver and kidney, and increased transcription is induced by anemia or cobalt chloride administration. To identify cis-acting DNA sequences responsible for regulated expression, transgenic mice were generated by microinjection of a 4-kilobase-pair (kb) (tgEPO4) or 10-kb (tgEPO10)...

Topics

Animals
Base Sequence
Blotting, Southern
Erythropoietin
Gene Expression Regulation
Kidney
Liver
Mice
Mice, Transgenic
Molecular Sequence Data
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poly A

RNA, Messenger

Regulatory Sequences, Nucleic Acid

Restriction Mapping

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2304468
DOI: 10.1128/mcb.10.3.930-938.1990
PMCID: PMC360936

Genes

EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2304468-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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