Article

Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice

2021-01-09

Abstract excerpt

The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia or other erythropoietic stimuli, and suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis. Suppression of hepcidin by ERFE is thought to be mediated by interference with paracrine BMP signaling that regulates hepcidin transcription in hepatocytes. In a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5f5ba3e-e7e6-534e-bafc-51e9f2282508
DOI: 10.1101/2021.01.09.426054

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in miceDOI 10.1101/2021.01.09.426054Read

Regulation of Human Erythroferrone ExpressionSemantic proximity Read

Erythropoiesis: Model systems, molecular regulators, and developmental programsSemantic proximity Read

The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive HematopoiesisSemantic proximity Read

Advances in understanding the mechanisms of erythropoiesis in homeostasis and diseaseSemantic proximity Read

Functional conservation of erythropoietin signaling in zebrafishSemantic proximity Read

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.Semantic proximity Read

EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesisSemantic proximity Read

Characterization of erythroferrone oligomerization and its impact on BMP antagonism.Semantic proximity Read

A mouse model for an erythropoietin-deficiency anemia.Semantic proximity Read

Identification and transcriptome analysis of erythroblastic island macrophagesSemantic proximity Read

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.Semantic proximity Read

Zebrafish erythropoiesis and the utility of fish as models of anemiaSemantic proximity Read