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Article

The Cre/loxP system and gene targeting in the kidney

1 May 1999

Abstract excerpt

The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby permitting study of the physiological and pathophysiological impact of a given gene product derived from a particular cell type. In the kidney, the Cre/loxP system has been employed to...

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Identifiers

PMID: 10330046
DOI: 10.1152/ajprenal.1999.276.5.f651

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