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Fount, fate, features, and function of renal erythropoietin-producing cells

24 Jun 2022

Abstract excerpt

Renal erythropoietin (Epo)-producing (REP) cells represent a rare and incompletely understood cell type. REP cells are fibroblast-like cells located in close proximity to blood vessels and tubules of the corticomedullary border region. Epo mRNA in REP cells is produced in a pronounced "on-off" mode, showing transient transcriptional bursts upon exposure to hypoxia. In contrast to "ordinary" fibroblasts, REP cells...

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PMID: 35750861
DOI: 10.1007/s00424-022-02714-7

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