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Article

A mouse model for an erythropoietin-deficiency anemia.

Disease models & mechanisms - 1 Jan 2000

Zeigler Brandon M, Vajdos Janis, Qin Wenning, Loverro Linda, Niss Knut

Abstract excerpt

In mammals, the production of red blood cells is tightly regulated by the growth factor erythropoietin (EPO). Mice lacking a functional Epo gene are embryonic lethal, and studying erythropoiesis in EPO-deficient adult animals has therefore been limited. In order to obtain a preclinical model for an EPO-deficient anemia, we developed a mouse in which Epo can be silenced by Cre recombinase. After induction of Cre...

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Source

Identifiers

PMID: 20959632
DOI: 10.1242/dmm.004788

Genes

EPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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