Article
The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence.
BMC evolutionary biology - 5 Dec 2016
Pajic Petar, Lin Yen-Lung, Xu Duo, Gokcumen Omer
Abstract excerpt
BACKGROUND: A common, 32kb deletion of LCE3B and LCE3C genes is strongly associated with psoriasis. We recently found that this deletion is ancient, predating Human-Denisovan divergence. However, it was not clear why negative selection has not removed this deletion from the population. RESULTS: Here, we show that the haplotype block that harbors the deletion (i) retains high allele frequency among extant and...
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