Article
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.
Nature genetics - 1 Feb 2009
de Cid Rafael, Riveira-Munoz Eva, Zeeuwen Patrick L J M, Robarge Jason, Liao Wilson, Dannhauser Emma N, Giardina Emiliano, Stuart Philip E, Nair Rajan, Helms Cynthia, Escaramís Georgia, Ballana Ester, Martín-Ezquerra Gemma, den Heijer Martin, Kamsteeg Marijke, Joosten Irma, Eichler Evan E, Lázaro Conxi, Pujol Ramón M, Armengol Lluís, Abecasis Gonçalo, Elder James T, Novelli Giuseppe, Armour John A L, Kwok Pui-Yan, Bowcock Anne, Schalkwijk Joost, Estivill Xavier
Abstract excerpt
Psoriasis is a common inflammatory skin disease with a prevalence of 2-3% in individuals of European ancestry. In a genome-wide search for copy number variants (CNV) using a sample pooling approach, we have identified a deletion comprising LCE3B and LCE3C, members of the late cornified envelope (...
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