Article
Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition.
The Journal of investigative dermatology - 1 Jul 2022
Niehues Hanna, van der Krieken Danique A, Ederveen Thomas H A, Jansen Patrick A M, van Niftrik Laura, Mesman Rob, Netea Mihai G, Smits Jos P H, Schalkwijk Joost, van den Bogaard Ellen H, Zeeuwen Patrick L J M
Abstract excerpt
Late cornified envelope proteins are predominantly expressed in the skin and other cornified epithelia. On the basis of sequence similarity, this 18-member homologous gene family has been subdivided into six groups. The LCE3 proteins have been the focus of dermatological research because the combined deletion of LCE3B and LCE3C genes (LCE3B/C-del) is a risk factor for psoriasis. We previously reported that...
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