Article
Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.
The Journal of investigative dermatology - 1 Aug 2011
Li Miaozhu, Wu Yumei, Chen Guoliang, Yang Yifeng, Zhou Daizhan, Zhang Zhou, Zhang Di, Chen Yinwei, Lu Zhiyong, He Lin, Zheng Jie, Liu Yun
Abstract excerpt
A common deletion comprising LCE3B and LCE3C, members of the late cornified envelope (LCE) gene cluster, has been shown to be significantly associated with psoriasis in several Caucasian populations. The expression of LCE can be induced by skin barrier disruption, leading to psoriatic lesions. To identify whether deletion of genes in the LCE region is a genetic risk factor in the pathogenesis of psoriasis, we...
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