Article
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
The Journal of investigative dermatology - 1 May 2011
Riveira-Munoz Eva, He Su-Min, Escaramís Georgia, Stuart Philip E, Hüffmeier Ulrike, Lee Catherine, Kirby Brian, Oka Akira, Giardina Emiliano, Liao Wilson, Bergboer Judith, Kainu Kati, de Cid Rafael, Munkhbat Batmunkh, Zeeuwen Patrick L J M, Armour John A L, Poon Annie, Mabuchi Tomotaka, Ozawa Akira, Zawirska Agnieszka, Burden A David, Barker Jonathan N, Capon Francesca, Traupe Heiko, Sun Liang-Dan, Cui Yong, Yin Xian-Yong, Chen Gang, Lim Henry W, Nair Rajan P, Voorhees John J, Tejasvi Trilokraj, Pujol Ramón, Munkhtuvshin Namid, Fischer Judith, Kere Juha, Schalkwijk Joost, Bowcock Anne, Kwok Pui-Yan, Novelli Giuseppe, Inoko Hidetoshi, Ryan Anthony W, Trembath Richard C, Reis André, Zhang Xue-Jun, Elder James T, Estivill Xavier
Abstract excerpt
A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European...
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