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Article

Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015

Pais June E, Dai Nan, Tamanaha Esta, Vaisvila Romualdas, Fomenkov Alexey I, Bitinaite Jurate, Sun Zhiyi, Guan Shengxi, Corrêa Ivan R, Noren Christopher J, Cheng Xiaodong, Roberts Richard J, Zheng Yu, Saleh Lana

Abstract excerpt

Modified DNA bases in mammalian genomes, such as 5-methylcytosine ((5m)C) and its oxidized forms, are implicated in important epigenetic regulation processes. In human or mouse, successive enzymatic conversion of (5m)C to its oxidized forms is carried out by the ten-eleven translocation (TET) proteins. Previously we reported the structure of a TET-like (5m)C oxygenase (NgTET1) from Naegleria gruberi, a...

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Identifiers

PMID: 25831492
DOI: 10.1073/pnas.1417939112
PMCID: PMC4394277

Genes

TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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