Article
In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck.
Cancer research - 15 Jun 2007
Li Donghui, Wang Li-E, Chang Ping, El-Naggar Adel K, Sturgis Erich M, Wei Qingyi
Abstract excerpt
In this large confirmatory study of 803 patients with squamous cell carcinoma of head and neck (SCCHN) and 839 controls frequency matched by age, sex, and ethnicity, we further examined potential predictors of benzo[a]pyrene diol epoxide (BPDE)-induced adduct levels and their associations with SCCHN risk. BPDE-DNA adduct levels were determined by the (32)P-postlabeling method in peripheral lymphocytes after in...
Topics
- Aged
- Alcohol Drinking
- Benzopyrenes
- Carcinogens
- Carcinoma, Squamous Cell
- Case-Control Studies
- DNA Adducts
- Female
- Genotype
- Glutathione S-Transferase pi
- Glutathione Transferase
- Head and Neck Neoplasms
- Humans
- In Vitro Techniques