Article
Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis.
Carcinogenesis - 1 Aug 2008
Zhao Hui, Wang Li-E, Li Donghui, Chamberlain Robert M, Sturgis Erich M, Wei Qingyi
Abstract excerpt
Benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts are a risk factor for tobacco-related cancers. Excision repair cross-complementing complementation group 1 (ERCC1) and excision repair cross-complementing complementation group 2/xeroderma pigmentosum D (ERCC2/XPD) participate in the nucleotide excision repair (NER) pathway that removes BPDE-DNA adducts; however, few studies have provided population-based...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- DNA Adducts
- DNA Repair
- DNA-Binding Proteins
- Endonucleases
- Genotype
- Humans
- Lymphocytes
- Phenotype
- Reference Values