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Article

Benzo[a]pyrene diol epoxide-induced 9p21 aberrations associated with genetic predisposition to bladder cancer.

Genes, chromosomes & cancer - 1 Dec 2004

Hazra Aditi, Grossman H Barton, Zhu Yong, Luo Sherry, Spitz Margaret R, Wu Xifeng

Abstract excerpt

CDKN2A, 9p21, encodes two alternatively spiked, functionally distinct, tumor-suppressor proteins, P16INK4A and P14ARF, which play active roles in the RB1 and TP53 pathways, respectively. Deletion of 9p is one of the most frequent genomic alterations in bladder cancer. In addition, alterations of 9p21 and P16 are frequently seen in the epithelial cells of chronic smokers. This pilot study evaluated whether 9p21...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Aged
Chromosome Aberrations
Chromosomes, Human, Pair 9
Female
Genetic Predisposition to Disease
Humans
In Situ Hybridization, Fluorescence
Lymphocytes
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutagens

Pilot Projects

Smoking

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 15390186
DOI: 10.1002/gcc.20093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15390186-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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