Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers.

doi:10.1093/carcin/bgh303

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Article

Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers.

Carcinogenesis - 1 Jan 2005

Pavanello Sofia, Pulliero Alessandra, Siwinska Ewa, Mielzynska Danuta, Clonfero Erminio

Abstract excerpt

It is important to identify the potential genetic-susceptible factors that are able to modulate individual responses to exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs). In the present study we evaluated the influence of four polymorphisms of nucleotide excision repair (NER) genes [xeroderma pigmentosum-C (XPC)-PAT +/-, xeroderma pigmentosum-A (XPA) 5' non-coding region-A23G, XPD-exon 23 A35931C...

Topics

Benzopyrenes
Chromatography, High Pressure Liquid
Coke
DNA Adducts
DNA Repair
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Occupational Exposure

Polycyclic Aromatic Hydrocarbons

Polymerase Chain Reaction

Polymorphism, Genetic

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 15471894
DOI: 10.1093/carcin/bgh303

Genes

GSTM1
PAH
XPA
XPC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15471894-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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