Article
Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity.
Carcinogenesis - 1 Oct 2006
Shen Min, Lan Qing, Zhang Luoping, Chanock Stephen, Li Guilan, Vermeulen Roel, Rappaport Stephen M, Guo Weihong, Hayes Richard B, Linet Martha, Yin Songnian, Yeager Meredith, Welch Robert, Forrest Matthew S, Rothman Nathaniel, Smith Martyn T
Abstract excerpt
Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic damage. DNA double-strand breaks (DSB) are one of the most severe DNA lesions caused directly and indirectly by benzene metabolites. DSB may lead to chromosome aberrations, apoptosis and hematopoietic progenitor cell suppression. We hypothesized that genetic polymorphisms in genes involved in DNA DSB repair may modify benzene-induced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.