Article
Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.
PloS one - 1 Jan 2016
Wang Huaishan, Zhai Kangle, Xue Yingchao, Yang Jia, Yang Qi, Fu Yi, Hu Yu, Liu Fang, Wang Weiqing, Cui Lianxian, Chen Hui, Zhang Jianmin, He Wei
Abstract excerpt
Translocator Protein (18kDa, TSPO) is a mitochondrial outer membrane transmembrane protein. Its expression is elevated during inflammation and injury. However, the function of TSPO in vivo is still controversial. Here, we constructed a TSPO global knockout (KO) mouse with a Cre-LoxP system that abolished TSPO protein expression in all tissues and showed normal phenotypes in the physiological condition. The birth...
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