Postnatally induced TBX4 insufficiency confers pulmonary hypertension and impairs lung development in infant mice.

Abstract excerpt

BACKGROUND: Genetic variants in T-box transcription factor 4 (TBX4) cause pulmonary hypertension (PH); however, there are diverse phenotypes with respect to the timing and severity of disease. Previous mouse studies demonstrated that germline TBX4 knockout is embryonic lethal, but knowledge gaps exist in how postnatal disruption of TBX4 signaling affects lung structure and PH. METHODS: A mouse model was used in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Animals, Newborn
• Share to Disease Models, Animal