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Article

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.

The Biochemical journal - 21 Nov 2017

Owen David R, Fan Jinjiang, Campioli Enrico, Venugopal Sathvika, Midzak Andrew, Daly Edward, Harlay Aline, Issop Leeyah, Libri Vincenzo, Kalogiannopoulou Dimitra, Oliver Eduardo, Gallego-Colon Enrique, Colasanti Alessandro, Huson Les, Rabiner Eugenii A, Suppiah Puvan, Essagian Charles, Matthews Paul M, Papadopoulos Vassilios

Abstract excerpt

The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial membrane protein implicated in numerous cell and tissue functions, including steroid hormone biosynthesis, respiration, cell proliferation, and apoptosis. TSPO binds with high affinity to cholesterol and numerous compounds, is expressed at high levels in steroid-synthesizing tissues, and mediates cholesterol import into...

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Identifiers

PMID: 29074640
DOI: 10.1042/BCJ20170648
PMCID: PMC5697202

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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