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Article

Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.

Bone - 1 Dec 2021

Alford Andrea I, Stephan Chris, Kozloff Kenneth M, Hankenson Kurt D

Abstract excerpt

The trimeric thrombospondin homologs, TSP1 and TSP2, are both components of bone tissue and contribute in redundant and distinct ways to skeletal physiology. TSP1-null mice display increased femoral cross-sectional area and thickness due to periosteal expansion, as well as diminished matrix quality and impaired osteoclast function. TSP2-null mice display increased femoral cross-sectional thickness and reduced...

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Identifiers

PMID: 34425286
DOI: 10.1016/j.bone.2021.116156
PMCID: PMC8478904

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