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Article

Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.

Biochemical Society transactions - 1 Aug 2015

Middleton Ryan J, Liu Guo-Jun, Banati Richard B

Abstract excerpt

The highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy...

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Identifiers

PMID: 26551692
DOI: 10.1042/BST20150039

Genes

TSPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.PMID 26551692Read ↗

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Translocator protein ligand Ro5-4864 promotes melanogenesis in a TSPO independent mannerSemantic proximity Read ↗

Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation ImagingSemantic proximity Read ↗

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission TomographySemantic proximity Read ↗

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.Semantic proximity Read ↗

Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.Semantic proximity Read ↗

A comprehensive functional investigation of the human translocator protein 18 kDa (TSPO) in a novel human neuronal cell knockout model: from molecule to depressionSemantic proximity Read ↗

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