Article

Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection

2020-06-18

Abstract excerpt

It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home with normally functioning lungs are also at risk for hyperreactivity after a respiratory viral infection suggesting neonatal oxygen may have induced hidden molecular changes that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ac325ce-7435-5a71-a87d-5d80d282d3b9
DOI: 10.1101/2020.06.17.157610

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A InfectionDOI 10.1101/2020.06.17.157610Read

Animal models of bronchopulmonary dysplasia. The term mouse modelsSemantic proximity Read

Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependentSemantic proximity Read

Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasiaSemantic proximity Read

Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasiaSemantic proximity Read

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury.Semantic proximity Read

High-mobility group box1 peptide ameliorates bronchopulmonary dysplasia via suppressing inflammation and fibrosis in a mouse modelSemantic proximity Read

Single-cell transcriptomics reveals lasting changes in the lung cellular landscape into adulthood after neonatal hyperoxic exposureSemantic proximity Read

Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasiaSemantic proximity Read

Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in miceSemantic proximity Read

Platelet Activating Factor Activity Modulates Hyperoxic Neonatal Lung Injury SeveritySemantic proximity Read

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injurySemantic proximity Read

Long-term effects of recurrent intermittent hypoxia and hyperoxia on respiratory system mechanics in neonatal mice.Semantic proximity Read