Article
Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury.
Nature immunology - 1 Aug 2025
Abe Yohei, Spann Nathanael J, Tang Wenxi, Zeng Fenghua, Seymour Cadence, Jansky Sean, Guo Jason L, Huff Robert, Chanthavixay Kelly, Richard John Lalith Charles, Mooney Miguel, Dhar Debanjan, Ganguly Souradipta, Lopez David M, Longaker Michael T, Benner Christopher, Glass Christopher K, Sajti Eniko
Abstract excerpt
Bronchopulmonary dysplasia is a common complication of preterm birth, driven in part by the inflammatory effects of supplemental oxygen on the immature lung. Although oxygen therapy is essential, it contributes to disrupted lung development but not all infants are equally susceptible. Using genetically diverse mouse models, we found that hyperoxia-sensitive mice exhibit a distinct innate immune response compared...
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