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Article

Analysis of knockout mice reveals critical female-specific roles for the Hippo pathway component PTPN14.

Genes & development - 2 Sept 2025

McCrea Edel M, Makrides Neoklis, Tabata Takako, Reineking Wencke, Vilches-Moure José G, Wang Mengxiong, Lake Julie S, Vogel Hannes, Howitt Brooke, Zhang Xin, Attardi Laura D

Abstract excerpt

The Hippo pathway regulates many physiological processes, including development, tumor suppression, and wound healing. One understudied Hippo pathway component is PTPN14, an evolutionarily conserved tyrosine phosphatase that inhibits YAP/TAZ. Although it is an established tumor suppressor, PTPN14's role in tissue homeostasis has remained unclear. We thus generated Ptpn14-deficient mice and found that only ∼60% of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 40533389
DOI: 10.1101/gad.352620.125
PMCID: PMC12404200

Genes

PTPN14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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