Article
Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes.
Oncotarget - 3 Jan 2017
Karyadi Danielle M, Geybels Milan S, Karlins Eric, Decker Brennan, McIntosh Laura, Hutchinson Amy, Kolb Suzanne, McDonnell Shannon K, Hicks Belynda, Middha Sumit, FitzGerald Liesel M, DeRycke Melissa S, Yeager Meredith, Schaid Daniel J, Chanock Stephen J, Thibodeau Stephen N, Berndt Sonja I, Stanford Janet L, Ostrander Elaine A
Abstract excerpt
Prostate cancer (PCa) susceptibility is defined by a continuum from rare, high-penetrance to common, low-penetrance alleles. Research to date has concentrated on identification of variants at the ends of that continuum. Taking an alternate approach, we focused on the important but elusive class of low-frequency, moderately penetrant variants by performing disease model-based variant filtering of whole exome...
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