Article
Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2013
Fitzgerald Liesel M, Kumar Akash, Boyle Evan A, Zhang Yuzheng, McIntosh Laura M, Kolb Suzanne, Stott-Miller Marni, Smith Tiffany, Karyadi Danielle M, Ostrander Elaine A, Hsu Li, Shendure Jay, Stanford Janet L
Abstract excerpt
BACKGROUND: Rare, inherited mutations account for 5% to 10% of all prostate cancer cases. However, to date, few causative mutations have been identified. METHODS: To identify rare mutations for prostate cancer, we conducted whole-exome sequencing (WES) in multiple kindreds (n = 91) from 19 hereditary prostate cancer (HPC) families characterized by aggressive or early-onset phenotypes. Candidate variants (n = 130)...
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