Article
A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.
Cancer research - 1 Apr 2021
Emami Nima C, Cavazos Taylor B, Rashkin Sara R, Cario Clinton L, Graff Rebecca E, Tai Caroline G, Mefford Joel A, Kachuri Linda, Wan Eunice, Wong Simon, Aaronson David, Presti Joseph, Habel Laurel A, Shan Jun, Ranatunga Dilrini K, Chao Chun R, Ghai Nirupa R, Jorgenson Eric, Sakoda Lori C, Kvale Mark N, Kwok Pui-Yan, Schaefer Catherine, Risch Neil, Hoffmann Thomas J, Van Den Eeden Stephen K, Witte John S
Abstract excerpt
To identify rare variants associated with prostate cancer susceptibility and better characterize the mechanisms and cumulative disease risk associated with common risk variants, we conducted an integrated study of prostate cancer genetic etiology in two cohorts using custom genotyping microarrays, large imputation reference panels, and functional annotation approaches. Specifically, 11,984 men (6,196 prostate...
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