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Article

Exome sequencing of affected duos and trios uncovers PRUNE2 as a novel prostate cancer predisposition gene.

British journal of cancer - 1 Apr 2023

Cardoso Marta, Maia Sofia, Brandão Andreia, Sahasrabudhe Ruta, Lott Paul, Belter Natalia, Carvajal-Carmona Luis G, Paulo Paula, Teixeira Manuel R

Abstract excerpt

BACKGROUND: Prostate cancer (PrCa) is one of the most hereditable human cancers, however, only a small fraction of patients has been shown to carry deleterious variants in known cancer predisposition genes. METHODS: Whole-exome sequencing was performed in multiple affected members of 45 PrCa families to select the best candidate genes behind part of the PrCa missing hereditability. Recurrently mutated genes were...

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Identifiers

PMID: 36564567
DOI: 10.1038/s41416-022-02125-6
PMCID: PMC10006409

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