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Whole-exome sequencing reveals a comprehensive germline mutation landscape and identifies twelve novel predisposition genes in Chinese prostate cancer patients.

PLoS genetics - 1 Sept 2022

Liang Yonghao, Chiu Peter Ka-Fung, Zhu Yao, Wong Christine Yim-Ping, Xiong Qing, Wang Lin, Teoh Jeremy Yuen-Chun, Cao Qin, Wei Yu, Ye Ding-Wei, Tsui Stephen Kwok-Wing, Ng Chi-Fai

Abstract excerpt

Prostate cancer is the most inheritable cancer with approximately 42% of disease risk attributed to inherited factors by studies of twins, indicating the importance of additional genetic screening to identify predisposition variants. However, only DNA damage repair (DDR) genes have been investigated thoroughly in prostate cancer. To determine the comprehensive germline mutation landscape in Chinese prostate...

Topics

China
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Male
Prostatic Neoplasms
Protein Kinases
Tyrosine
Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36095024
DOI: 10.1371/journal.pgen.1010373
PMCID: PMC9499300

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