Article
Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases.
Nature communications - 19 Feb 2025
Mitchell Jonathan, Camacho Niedzica, Shea Patrick, Stopsack Konrad H, Joseph Vijai, Burren Oliver S, Dhindsa Ryan S, Nag Abhishek, Berchuck Jacob E, O'Neill Amanda, Abbasi Ali, Zoghbi Anthony W, Alegre-Díaz Jesus, Kuri-Morales Pablo, Berumen Jaime, Tapia-Conyer Roberto, Emberson Jonathan, Torres Jason M, Collins Rory, Wang Quanli, Goldstein David, Matakidou Athena, Haefliger Carolina, Anderson-Dring Lauren, March Ruth, Jobanputra Vaidehi, Dougherty Brian, Carss Keren, Petrovski Slavé, Kantoff Philip W, Offit Kenneth, Mucci Lorelei A, Pomerantz Mark, Fabre Margarete A
Abstract excerpt
To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array data. At the gene level, our case-control collapsing analysis confirms associations between rare damaging variants...
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