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Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases

19 Feb 2025

Abstract excerpt

Abstract To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array data. At the gene level, our case-control collapsing analysis confirms associations between rare damaging...

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PMID: 39971927
DOI: 10.1038/s41467-025-56944-1

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