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Generation of two induced pluripotent stem cell lines from patients with Li-Fraumeni Syndrome carrying TP53 mutation.

Stem cell research - 1 Dec 2024

Sun Junyi, Ren Lu, Canel Rivero Gabriela, Xu Lingyun, Ladabaum Uri, C Wu Joseph

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant inherited genetic disorder that greatly increases the risk of developing several types of cancer, including young children and young adults. LFS is primarily caused by specific mutations in the tumor suppressor gene TP53. In this study, we successfully generated two human induced pluripotent stem cell (iPSC) lines derived from patients diagnosed with LFS,...

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Identifiers

PMID: 39133963
DOI: 10.1016/j.scr.2024.103527

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