Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions.

doi:10.1371/journal.pone.0118307

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Article

Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions.

PloS one - 1 Jan 2015

Garitaonandia Ibon, Amir Hadar, Boscolo Francesca Sesillo, Wambua Gerald K, Schultheisz Heather L, Sabatini Karen, Morey Robert, Waltz Shannon, Wang Yu-Chieh, Tran Ha, Leonardo Trevor R, Nazor Kristopher, Slavin Ileana, Lynch Candace, Li Yingchun, Coleman Ronald, Gallego Romero Irene, Altun Gulsah, Reynolds David, Dalton Stephen, Parast Mana, Loring Jeanne F, Laurent Louise C

Abstract excerpt

The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs) make them a promising source of material for cell transplantation therapy, drug development, and studies of cellular differentiation and development. However, the large numbers of cells necessary for many of these applications require extensive expansion of hPSC cultures, a process that has been associated with genetic and...

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PMID: 25714340
DOI: 10.1371/journal.pone.0118307
PMCID: PMC4340884

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