Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus.

doi:10.1016/j.imlet.2016.11.011

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Article

Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus.

Immunology letters - 1 Jan 2017

D'Amico Fabio, Skarmoutsou Evangelia, Lo Lauren J, Granata Mariagrazia, Trovato Chiara, Rossi Giulio A, Bellocchi Chiara, Marchini Maurizio, Scorza Raffaella, Mazzarino Maria Clorinda, Keinan Alon

Abstract excerpt

Autoimmune diseases often share common susceptibility genes. Most genetic variants associated with susceptibility to systemic lupus erythematosus are also associated with other autoimmune diseases. The X-linked variant rs2294020 is positioned in exon 7 of the CCDC22 gene. The encoded protein functions in the regulation of NF-κB, a master regulator in immune response. The aim of this study is to investigate...

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Identifiers

PMID: 27888057
DOI: 10.1016/j.imlet.2016.11.011
PMCID: PMC5222889

Genes

CCDC22

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