Article
The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus.
Genes and immunity - 1 Dec 2011
Bronson P G, Goldstein B A, Ramsay P P, Beckman K B, Noble J A, Lane J A, Seldin M F, Kelly J A, Harley J B, Moser K L, Gaffney P M, Behrens T W, Criswell L A, Barcellos L F
Abstract excerpt
The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor required for human leukocyte antigens (HLA) class II MHC-restricted antigen presentation. MHC genes, including the HLA class II DRB1*03:01 allele, are strongly associated with systemic lupus erythematosus (SLE). Recently the rs4774 CIITA missense variant (+1632G/C) was reported to be...
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