Article
Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus.
Arthritis research & therapy - 20 Mar 2015
Zhang Yan, Wang Yong-Fei, Yang Jing, Zhang Jing, Sun Liangdan, Hirankarn Nattiya, Pan Hai-Feng, Lau Chak Sing, Chan Tak Mao, Lee Tsz Leung, Leung Alexander Moon Ho, Mok Chi Chiu, Zhang Lu, Shen Jiangshan Jane, Wong Sik Nin, Lee Ka Wing, Ho Marco Hok Kung, Lee Pamela Pui Wah, Chung Brian Hon-Yin, Chong Chun Yin, Wong Raymond Woon Sing, Mok Mo Yin, Wong Wilfred Hing Sang, Tong Kwok Lung, Tse Niko Kei Chiu, Li Xiang-Pei, Avihingsanon Yingyos, Rianthavorn Pornpimol, Deekajorndej Thavatchai, Suphapeetiporn Kanya, Shotelersuk Vorasuk, Ying Shirley King Yee, Fung Samuel Ka Shun, Lai Wai Ming, Wong Chun-Ming, Ng Irene Oi Lin, Garcia-Barcelo Maria-Merce, Cherny Stacey S, Tam Paul Kwong-Hang, Sham Pak Chung, Yang Sen, Ye Dong Qing, Cui Yong, Zhang Xue-Jun, Yang Wanling, Lau Yu Lung
Abstract excerpt
INTRODUCTION: Systemic lupus erythematosus (SLE) is a heterogeneous disease with a diverse spectrum of clinical symptoms, ranging from skin rash to end-organ damage. 22q11.21 has been identified as a susceptibility region for several autoimmune diseases, including SLE. However, detailed information for SLE association and the underlying functional mechanism(s) is still lacking. METHODS: Through meta-analysis of...
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