Article
A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis.
Clinical and experimental rheumatology - 1 Jan 2000
Koumakis Eugenie, Bouaziz Matthieu, Dieudé Philippe, Cauvet Anne, Ruiz Barbara, Airò Paolo, Cusi Daniele, Matucci-Cerinic Marco, Salvi Erika, Cuomo Giovanna, Hachulla Eric, Diot Elisabeth, Caramaschi Paola, Riccieri Valeria, Avouac Jerome, Allanore Yannick
Abstract excerpt
OBJECTIVES: Systemic sclerosis (SSc) is a rare autoimmune disease (AID) with a complex genetic etiology. Evidence for a shared pathogenesis across AIDs is given by the well-known pleiotropism of autoimmune genes. Recently, several unbiased approaches have identified an association between polymorphisms of the CD2 gene, and rheumatoid arthritis (RA) susceptibility. The objective of this study was to investigate...
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