Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.

doi:10.1002/art.21049

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Article

Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.

Arthritis and rheumatism - 1 Jun 2005

Hinks Anne, Barton Anne, John Sally, Bruce Ian, Hawkins Clive, Griffiths Christopher E M, Donn Rachelle, Thomson Wendy, Silman Alan, Worthington Jane

Abstract excerpt

OBJECTIVE: The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T cells and B cells. A missense single-nucleotide polymorphism (SNP) within this gene (rs2476601) has recently been associated with 4 autoimmune diseases: rheumatoid arthritis (RA), systemic lupus erythematosus, autoimmune thyroid disease, and type 1 diabetes mellitus, all of which are T cell-mediated and...

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Identifiers

PMID: 15934099
DOI: 10.1002/art.21049

Genes

PTPN22

Provenance

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