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Article

Physical Activity, Energy Expenditure, and Defense of Body Weight in Melanocortin 4 Receptor-Deficient Male Rats.

Scientific reports - 25 Nov 2016

Almundarij Tariq I, Smyers Mark E, Spriggs Addison, Heemstra Lydia A, Beltz Lisa, Dyne Eric, Ridenour Caitlyn, Novak Colleen M

Abstract excerpt

Melanocortin 4 receptor (MC4R) variants contribute to human obesity, and rats lacking functional MC4R (Mc4rK314X/K314X) are obese. We investigated the hypothesis that low energy expenditure (EE) and physical activity contribute to this obese phenotype in male rats, and determined whether lack of functional MC4R conferred protection from weight loss during 50% calorie restriction. Though Mc4rK314X/K314X rats...

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Identifiers

PMID: 27886210
DOI: 10.1038/srep37435
PMCID: PMC5122857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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