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Article

Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2009

Haskell-Luevano Carrie, Schaub Jay W, Andreasen Amy, Haskell Kim R, Moore Marcus C, Koerper Lorraine M, Rouzaud Francois, Baker Henry V, Millard William J, Walter Glenn, Litherland S A, Xiang Zhimin

Abstract excerpt

Exercise is a mechanism for maintenance of body weight in humans. Morbidly obese human patients have been shown to possess single nucleotide polymorphisms in the melanocortin-4 receptor (MC4R). MC4R knockout mice have been well characterized as a genetic model that possesses phenotypic metabolic disorders, including obesity, hyperphagia, hyperinsulinemia, and hyperleptinemia, similar to those observed in humans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

Source

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Identifiers

PMID: 18971258
DOI: 10.1096/fj.08-109686
PMCID: PMC2630780

Genes

NPY
POMC
AGRP
BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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