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Article

Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2012

Mul Joram D, Begg Denovan P, Alsters Suzanne I M, van Haaften Gijs, Duran Karen J, D'Alessio David A, le Roux Carel W, Woods Stephen C, Sandoval Darleen A, Blakemore Alexandra I F, Cuppen Edwin, van Haelst Mieke M, Seeley Randy J

Abstract excerpt

Bariatric surgery is currently the most effective treatment for obesity. Vertical sleeve gastrectomy (VSG), a commonly applied bariatric procedure, involves surgically incising most of the volume of the stomach. In humans, partial loss of melanocortin receptor-4 (MC4R) activity is the most common monogenic correlate of obesity regardless of lifestyle. At present it is unclear whether genetic alteration of MC4R...

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Identifiers

PMID: 22535749
DOI: 10.1152/ajpendo.00159.2012
PMCID: PMC3404562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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