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Article

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.

Nature genetics - 1 Sept 2000

Chen A S, Marsh D J, Trumbauer M E, Frazier E G, Guan X M, Yu H, Rosenblum C I, Vongs A, Feng Y, Cao L, Metzger J M, Strack A M, Camacho R E, Mellin T N, Nunes C N, Min W, Fisher J, Gopal-Truter S, MacIntyre D E, Chen H Y, Van der Ploeg L H

Abstract excerpt

Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has remained unknown. We evaluated the potential role of Mc3r in energy homeostasis by studying Mc3r-deficient (Mc3r(-/-)) mice and compared the functions of Mc3r and Mc4r in...

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PMID: 10973258
DOI: 10.1038/79254

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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.PMID 10973258Read ↗

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