Article
Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis.
The Journal of biological chemistry - 25 Nov 2011
Begriche Karima, Levasseur Peter R, Zhang Jingying, Rossi Jari, Skorupa Danielle, Solt Laura A, Young Brandon, Burris Thomas P, Marks Daniel L, Mynatt Randall L, Butler Andrew A
Abstract excerpt
The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition, natriuresis, immune function, and entrainment of circadian rhythms to nutrient intake. MC3Rs are expressed in hypothalamic and limbic regions of the brain and in peripheral tissues. To investigate the roles of central MC3Rs, we inserted a "lox-stop-lox" (LoxTB) 5' of the translation initiation codon of the mouse Mc3r gene and...
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