Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.

doi:10.1038/oby.2009.233

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Article

Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.

Obesity (Silver Spring, Md.) - 1 Oct 2009

Haupt Axel, Thamer Claus, Heni Martin, Tschritter Otto, Machann Jürgen, Schick Fritz, Machicao Fausto, Häring Hans-Ulrich, Staiger Harald, Fritsche Andreas

Abstract excerpt

Polymorphisms near the melanocortin-4 receptor (MC4R) gene locus are associated with body weight. Recent studies have shown that they influence insulin sensitivity and incidence of the metabolic syndrome. Thus, we hypothesized that the candidate single-nucleotide polymorphism (SNP) rs17782313 near MC4R additionally influences body fat distribution and its change during lifestyle intervention. To test this, 343...

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PMID: 19629057
DOI: 10.1038/oby.2009.233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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