Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.

Diabetes - 1 Dec 2008

Krakoff Jonathan, Ma Lijun, Kobes Sayuko, Knowler William C, Hanson Robert L, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure. RESEARCH DESIGN AND METHODS: We investigated the association of two MC4R variants, Arg165Gln (R165Q) an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arizona
Share to Basal Metabolism
Share to Frameshift Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamine

Share to Hyperinsulinism

Share to Hyperphagia

Share to Indians, North American

Share to Receptor, Melanocortin, Type 4

Source

Open in PubMed Open full text

Identifiers

PMID: 18835933
DOI: 10.2337/db08-0577
PMCID: PMC2584132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18835933-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.PMID 18835933Read ↗

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.Semantic proximity Read ↗

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.Semantic proximity Read ↗

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.Semantic proximity Read ↗

Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians.Semantic proximity Read ↗

Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians.Semantic proximity Read ↗

Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.Semantic proximity Read ↗

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.Semantic proximity Read ↗

Identification and functional analysis of novel human melanocortin-4 receptor variants.Semantic proximity Read ↗

Polymorphisms and mutations in the melanocortin-3 receptor and their relation to human obesity.Semantic proximity Read ↗

Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.Semantic proximity Read ↗

A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol.Semantic proximity Read ↗

Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.