Article
UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2015
Wanders Desiree, Burk David H, Cortez Cory C, Van Nancy T, Stone Kirsten P, Baker Mollye, Mendoza Tamra, Mynatt Randall L, Gettys Thomas W
Abstract excerpt
Dietary methionine restriction (MR) by 80% increases energy expenditure (EE), reduces adiposity, and improves insulin sensitivity. We propose that the MR-induced increase in EE limits fat deposition by increasing sympathetic nervous system-dependent remodeling of white adipose tissue and increasing uncoupling protein 1 (UCP1) expression in both white and brown adipose tissue. In independent assessments of the...
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