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Article

Secisbp2 is essential for embryonic development and enhances selenoprotein expression.

Antioxidants & redox signaling - 20 Aug 2014

Seeher Sandra, Atassi Tarik, Mahdi Yassin, Carlson Bradley A, Braun Doreen, Wirth Eva K, Klein Marc O, Reix Nathalie, Miniard Angela C, Schomburg Lutz, Hatfield Dolph L, Driscoll Donna M, Schweizer Ulrich

Abstract excerpt

AIMS: The selenocysteine insertion sequence (SECIS)-binding protein 2 (Secisbp2) binds to SECIS elements located in the 3'-untranslated region of eukaryotic selenoprotein mRNAs. Selenoproteins contain the rare amino acid selenocysteine (Sec). Mutations in SECISBP2 in humans lead to reduced selenoprotein expression thereby affecting thyroid hormone-dependent growth and differentiation processes. The most severe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24274065
DOI: 10.1089/ars.2013.5358
PMCID: PMC4116110

Genes

SECISBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Secisbp2 is essential for embryonic development and enhances selenoprotein expression.PMID 24274065Read ↗

<i>SECISBP2</i> Deficiency Causes a Lethal Perinatal CardiomyopathySemantic proximity Read ↗

Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency.Semantic proximity Read ↗

Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.Semantic proximity Read ↗

Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.Semantic proximity Read ↗

Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions.Semantic proximity Read ↗

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans.Semantic proximity Read ↗

A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish BoySemantic proximity Read ↗

Selenoprotein-related disease in a young girl caused by nonsense mutations in the SBP2 gene.Semantic proximity Read ↗

Severe neurodevelopmental phenotype, diagnostic, and treatment challenges in patients with SECISBP2 deficiency.Semantic proximity Read ↗

Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2.Semantic proximity Read ↗

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.Semantic proximity Read ↗

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